DNA Gyrase-IN-4

Names

[ CAS No. ]:
2416400-32-1

[ Name ]:
DNA Gyrase-IN-4

Biological Activity

[Description]:

DNA Gyrase-IN-4 (compound 8p) is a potent DNA gyrase inhibitor, with an IC50 of 0.13 μM. DNA Gyrase-IN-4 shows excellent antibacterial activity against Staphylococcus aureus, Listeria monocytogenes, Salmonella and Escherichia coli, with MIC values of 0.05, 0.05, 0.05, and 8 μg/mL, respectively[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
Signaling Pathways >> Anti-infection >> Bacterial

[Target]

IC50: 0.13 μM (DNA gyrase)[1]


[References]

[1]. Liu H, et al. Novel coumarin-thiazolyl ester derivatives as potential DNA gyrase Inhibitors: Design, synthesis, and antibacterial activity. Bioorg Chem. 2020 Jul;100:103907.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H15Cl2NO4S

[ Molecular Weight ]:
460.33

Related Compounds