Aurora kinase inhibitor-10

Names

[ CAS No. ]:
2417228-90-9

[ Name ]:
Aurora kinase inhibitor-10

Biological Activity

[Description]:

Aurora kinase inhibitor-10 (Compound 6c) is an orally active Aurora B inhibitor with an IC50 of 8 nM. Aurora kinase inhibitor-10 shows antitumor activity[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Aurora Kinase
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase

[Target]

Aurora B:8 nM (IC50)


[In Vitro]

Aurora kinase inhibitor-10 (Compound 6c) shows antiproliferation activity with IC50 values of 0.57 ± 0.23, 0.42 ± 0.20, 0.69 ± 0.30, 3.97 ± 0.67 and 1.53 ± 0.52 µM against MCF-7, MDA-MB 231, SkoV3, A375 and A549, respectively[1].

[References]

[1]. Tamizharasan N, et al. Discovery and optimization of novel phenyldiazepine and pyridodiazepine based Aurora kinase inhibitors. Bioorg Chem. 2020 Jun;99:103800.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H19F5N6O4S

[ Molecular Weight ]:
546.47

Related Compounds