Aurora kinase inhibitor-9

Names

[ CAS No. ]:
2419107-09-6

[ Name ]:
Aurora kinase inhibitor-9

Biological Activity

[Description]:

Aurora kinase inhibitor-9 (compound 9d) is a potent AURKA/B dual aurora kinase inhibitor with IC50s of 0.093, 0.09 µM for Aurora A, Aurora B, respectively. Aurora kinase inhibitor-9 shows broad spectrum anti-proliferative activity[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Aurora Kinase
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase

[Target]

Aurora A:0.093 μM (IC50)

Aurora B:0.09 μM (IC50)


[References]

[1]. Al-Sanea MM, et al. Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights. Bioorg Med Chem. 2020 Jul 1;28(13):115525.

Chemical & Physical Properties

[ Molecular Formula ]:
C19H17Cl2N3O4S

[ Molecular Weight ]:
454.33

Related Compounds