VEGFR-2-IN-22

Names

[ CAS No. ]:
2447587-73-5

[ Name ]:
VEGFR-2-IN-22

Biological Activity

[Description]:

VEGFR-2-IN-22 (Compound 25) is a dual VEGFR-2 and β-tubulin polymerization inhibitor with an IC50 of 19.82 nM against VEGFR-2. VEGFR-2-IN-22 induces apoptosis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[Target]

VEGFR2:19.82 nM (IC50)


[In Vitro]

VEGFR-2-IN-22 (Compound 25) shows inhibition with an IC50 of 0.24 ± 0.06 µM against HepG2[1].

[References]

[1]. Abdelhameid MK, et al. Design, synthesis, and cytotoxic screening of novel azole derivatives on hepatocellular carcinoma (HepG2 Cells). Bioorg Chem. 2020 Aug;101:103995.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H24ClFN4O6

[ Molecular Weight ]:
542.94

Related Compounds