CDK8-IN-10

Names

[ CAS No. ]:
2457317-40-5

[ Name ]:
CDK8-IN-10

Biological Activity

[Description]:

CDK8-IN-10 (compound 2) is a potent, selective cyclin-dependent kinase (CDK8) inhibitor with an IC50 value of 8.25 nM. CDK8-IN-10 can be used for research of cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK8:8.25 nM (IC50)


[In Vitro]

CDK8-IN-10 (compound 2; 8 h; SW620 cells) reduces phosphorylation of CDK8 substrate STAT1 in cells with an IC50 value of 1.3 µM[1].

[References]

[1]. Martínez-González S, et, al. Pyrido[2,3-b][1,5]benzoxazepin-5(6H)-one derivatives as CDK8 inhibitors. Eur J Med Chem. 2020 Sep 1;201:112443.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H15ClF3N5O3

[ Molecular Weight ]:
525.87

Related Compounds