CDK1/Cyc B-IN-1

Names

[ CAS No. ]:
2459916-56-2

[ Name ]:
CDK1/Cyc B-IN-1

Biological Activity

[Description]:

CDK1/Cyc B-IN-1 (Compound 5) is a selective CDK1/Cyc B complex inhibitor with an IC50 of 97 nM. CDK1/Cyc B-IN-1 triggers apoptosis and G2/M cell cycle arrest. CDK1/Cyc B-IN-1 shows broad-spectrum cytotoxic action against cancer cell lines[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis
Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK1-Cyclin B:97 nM (IC50)


[In Vitro]

CDK1/Cyc B-IN-1 (Compound 5) shows cytotoxic activity with IC50 values of 5.33 ± 0.69 µM and 21.69 ± 1.04 µM against HCT-116 and WI-38, respectively[1].

[References]

[1]. Mohamed SH, et al. An investigative study of antitumor properties of a novel thiazolo[4,5-d]pyrimidine small molecule revealing superior antitumor activity with CDK1 selectivity and potent pro-apoptotic properties. Bioorg Med Chem. 2020 Sep 1;28(17):115633.

Chemical & Physical Properties

[ Molecular Formula ]:
C14H12ClN3O2S2

[ Molecular Weight ]:
353.85

Related Compounds