Tubulin polymerization-IN-27

Names

[ CAS No. ]:
2462030-32-4

[ Name ]:
Tubulin polymerization-IN-27

Biological Activity

[Description]:

Tubulin polymerization-IN-27 (compound 5j) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-27 can arrest cell cycle at G2/M phase and induce apoptosis[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[References]

[1]. Wang G, et, al. Design, synthesis, molecular modeling, and biological evaluation of pyrazole-naphthalene derivatives as potential anticancer agents on MCF-7 breast cancer cells by inhibiting tubulin polymerization. Bioorg Chem. 2020 Oct;103:104141.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H20N2O2

[ Molecular Weight ]:
344.41

Related Compounds