MAPK-IN-1
Names
[ CAS No. ]:
2470587-69-8
[ Name ]:
MAPK-IN-1
Biological Activity
[Description]:
MAPK-IN-1 (Compound 2) is a MAPK signaling pathway inhibitor. MAPK-IN-1 exhibits AChE inhibitory activity with an IC50 of 23.84 μM. MAPK-IN-1 shows anti-neuroinflammatory and neuroprotective activity and can be used for Alzheimer's disease research[1].
[Related Catalog]:
[Target]
TLR4
[In Vitro]
MAPK-IN-1 (Compound 2) inhibits NO, IL-1β, IL-6, and TNF-α release in BV-2 cells with IC50 values of 0.49 ± 0.17, 1.34 ± 0.21, 9.17 ± 0.17 and 8.17 ± 0.23 μM, respectively[1]. MAPK-IN-1 downregulates LPS-induced phosphorylation of JNK, ERK, and p38 in MAPK signaling pathway[1]. MAPK-IN-1 inhibits expressions of iNOS, COX-2, and TLR4 in LPS-induced BV-2 cells[1].
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C19H18O4
[ Molecular Weight ]:
310.34