Tubulin polymerization-IN-25
Names
[ CAS No. ]:
2490538-46-8
[ Name ]:
Tubulin polymerization-IN-25
Biological Activity
[Description]:
Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor of tubulin polymerization and farnesyl transferase (FTase) with IC50s of 1.11 μM and 0.39 μM, respectively. Tubulin polymerization-IN-25 displays cytotoxicity and excellent antitumor activity [1].
[Related Catalog]:
[Target]
IC50: 1.11 μM (Tubulin); 0.39 μM (FTase)[1]
[In Vitro]
Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor (MTI-FTI hybrids) acting on tubulin polymerization and on FTase[1]. Tubulin polymerization-IN-25 (10 μM, 48 h) inhibits cells growth and induces cell cytotoxicity on multiple cancer cell lines[1]. Cell Viability Assay[1] Cell Line: Leukemia cells: SR, CCRF-CEM, K-562; lung cancer cell CCRF-CEMNCI-H522; melanoma cell M14 Concentration: 10 μM Incubation Time: 48 hours Result: Inhibited cell growth. Cell Cytotoxicity Assay[1] Cell Line: NCI-H522 (lung cancer), COLO-205 and HT29 (colon cancer), SF-539 (human glioblastoma), MDA-MB-435 (melanoma), OVCAR-3 (ovarian cancer) and A498 (renal cancer) Concentration: 10 μM Incubation Time: 48 hours Result: Induced cell cytotoxicity.
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C24H18N2O3S
[ Molecular Weight ]:
414.48