Antitumor agent-68

Antitumor agent-68 is a potent tubulin inhibitor. Antitumor agent-68 shows potent anticancer activity with IC50s of 3.6 and 3.8 µM for HeLa and MCF-7 cells, respectively. Antitumor agent-68 exhibits good scavenging activity of ROS and DPPH radical in a dose-dependent manner[1].

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin

Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

IC50: 3.6 μM (HeLa), 3.8 µM (MCF-7)[1]

Antitumor agent-68 (Compound 7) exhibits anticancer activity with IC50s of 3.6 and 3.8 μM, for HeLa and MCF-7 cells, respectively[1]. Antitumor agent-68 (10 μΜ; 24 hours) causes a 3-fold reduction of ROS production induced by Men in 3T3-L1 cells, and an EC50 of DPPH radical scavenging is 8.30 µg/mL[1]. Cell Viability Assay[1] Cell Line: HeLa, MCF-7, 3T3-L1 Concentration: 10 μM Incubation Time: 24 hours Result: Showed anticancer activity by blocking the tubulin polymerization reaction. Reduced production of ROS, and scavenged DPPH radical.

[1]. Domenico Iacopetta, et al. Synthesis, anticancer and antioxidant properties of new indole and pyranoindole derivatives. Bioorg Chem. 2020 Dec;105:104440.