CDK4/6-IN-8

Names

[ CAS No. ]:
2649120-22-7

[ Name ]:
CDK4/6-IN-8

Biological Activity

[Description]:

CDK4/6-IN-8 (Compound 7p) is a selective CDK4 and CDK6 inhibitor with IC50 values of 5.01 nM and 3.97 nM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[Target]

CDK4:5.01 nM (IC50)

CDK6:3.97 nM (IC50)


[In Vitro]

CDK4/6-IN-8 (Compound 7p) (0-656.1 µM, 48 h) shows anti-breast cancer activity[1]. Cell Viability Assay[1] Cell Line: MCF-7 Concentration: 0.1, 0.3, 0.9, 2.7, 8.1, 24.3, 72.9, 218.7 and 656.1 µM Incubation Time: 48 h Result: Inhibited cell viability with an IC50 of 2.8 μM.

[References]

[1]. Liang JW, et al. Synthesis and identification of a novel skeleton of N-(pyridin-3-yl) proline as a selective CDK4/6 inhibitor with anti-breast cancer activities. Bioorg Chem. 2022 Feb;119:105547.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H18N6O5

[ Molecular Weight ]:
398.37

Related Compounds