2′-Deoxy-8-(methylthio)adenosine

Names

[ CAS No. ]:
29836-02-0

[ Name ]:
2′-Deoxy-8-(methylthio)adenosine

[Synonym ]:
8-methylsulfanyl-2'-deoxy-adenosine
8-methylthio-2'-deoxyadenosine

Biological Activity

[Description]:

2′-Deoxy-8-(methylthio)adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C12H17N5O2S

[ Molecular Weight ]:
295.36

[ Exact Mass ]:
297.09000

[ PSA ]:
144.61000

[ LogP ]:
0.35230

Related Compounds