2’-O-Methyl-4-thiouridine

Names

[ CAS No. ]:
34218-80-9

[ Name ]:
2’-O-Methyl-4-thiouridine

[Synonym ]:
1-(2-O-Methyl-β-D-ribofuranosyl)-4-thioxo-3,4-dihydro-2(1H)-pyrimidinone
2(1H)-Pyrimidinone, 3,4-dihydro-1-(2-O-methyl-β-D-ribofuranosyl)-4-thioxo-

Biological Activity

[Description]:

2’-O-Methyl-4-thiouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
Research Areas >> Others

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C10H14N2O5S

[ Molecular Weight ]:
274.29

[ Exact Mass ]:
274.062347

[ LogP ]:
0.00

[ Index of Refraction ]:
1.664

Related Compounds