2'-Deoxy-2'-fluorouridine

Names

[ CAS No. ]:
362049-50-1

[ Name ]:
2'-Deoxy-2'-fluorouridine

[Synonym ]:
2'-Deoxy-2'-fluorouridine
Uridine, 2'-deoxy-2'-fluoro-
2'-Fluoro-2'-deoxyuridine

Biological Activity

[Description]:

2'-Deoxy-2'-fluorouridine-d2 is the deuterium labeled 2'-Deoxy-2'-fluorouridine[1]. 2'-Deoxy-2'-fluorouridine can be used as an intermediate for antiinfluenza virus agents synthesis[2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Influenza Virus
Research Areas >> Infection

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. J V Tuttle, et al. Purine 2'-deoxy-2'-fluororibosides as antiinfluenza virus agents. J Med Chem  

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C9H9D2FN2O5

[ Molecular Weight ]:
246.192

[ Exact Mass ]:
246.065201

[ PSA ]:
104.55000

[ LogP ]:
-1.31

[ Index of Refraction ]:
1.608

Related Compounds