8-Chloro-2’-O-methyl adenosine

Names

[ CAS No. ]:
634207-55-9

[ Name ]:
8-Chloro-2’-O-methyl adenosine

[Synonym ]:
Adenosine,8-chloro-2'-O-methyl

Biological Activity

[Description]:

8-Chloro-2’-O-methyl adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.  

[2]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

Chemical & Physical Properties

[ Molecular Formula ]:
C11H14ClN5O4

[ Molecular Weight ]:
315.71

[ Exact Mass ]:
315.07300

[ PSA ]:
128.54000

Related Compounds