EGFR/HER2/CDK9-IN-1

Names

[ CAS No. ]:
879730-44-6

[ Name ]:
EGFR/HER2/CDK9-IN-1

Biological Activity

[Description]:

EGFR/HER2/CDK9-IN-1 (Compound 4) is a potent inhibitor of EGFR/HER2/CDK9 with IC50s of 90.17, 131.39, and 67.04 nM, respectively. EGFR/HER2/CDK9-IN-1 exhibits remarkable antitumor activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> JAK/STAT Signaling >> EGFR
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[References]

[1]. El-Azab AS, et al. Antitumor activity, multitarget mechanisms, and molecular docking studies of quinazoline derivatives based on a benzenesulfonamide scaffold: Cell cycle analysis. Bioorg Chem. 2020;104:104345.

Chemical & Physical Properties

[ Molecular Formula ]:
C23H21N3O3S2

[ Molecular Weight ]:
451.56

Related Compounds