Tubulin inhibitor 12

Names

[ CAS No. ]:
92575-00-3

[ Name ]:
Tubulin inhibitor 12

Biological Activity

[Description]:

Tubulin inhibitor 12 (Hit 9) is a novel tubulin inhibitor (IC50=25.3 μM). Tubulin inhibitor 12 shows anti-tumor activity and anti-proliferative activity[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin
Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin

[In Vitro]

Tubulin inhibitor 12 (0-100 μM; 72 h) shows moderate and broad-spectrum anti-proliferative activity[1]. Cell Proliferation Assay[1] Cell Line: HepG2, A549, and HCT116 cells Concentration: 0-100 μM Incubation Time: 72 hours Result: Showed IC50 values of 49.13, 52.84, and 70.10 μM for HepG2, A549, and HCT116 cells, respectively.

[References]

[1]. Wei Liu, et al. Discovery of novel tubulin inhibitors targeting the colchicine binding site via virtual screening, structural optimization and antitumor evaluation. Bioorg Chem. 2022 Jan;118:105486.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H20N2O

[ Molecular Weight ]:
352.43

Related Compounds