N-[2-[4-(1-Methylethyl)phenoxy]acetyl]guanosine

Names

[ CAS No. ]:
937205-20-4

[ Name ]:
N-[2-[4-(1-Methylethyl)phenoxy]acetyl]guanosine

[Synonym ]:
N-[(4-Isopropylphenoxy)acetyl]guanosine
Guanosine, N-[2-[4-(1-methylethyl)phenoxy]acetyl]-

Biological Activity

[Description]:

N-[2-[4-(1-Methylethyl)phenoxy]acetyl]guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7)[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6646-51.  

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Molecular Formula ]:
C21H25N5O7

[ Molecular Weight ]:
459.45

[ Exact Mass ]:
459.175385

[ LogP ]:
1.59

[ Index of Refraction ]:
1.720

Related Compounds