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  • DC Chemicals Limited
  • China
  • Product Name: WRW4
  • Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

878557-55-2

878557-55-2 structure
878557-55-2 structure
  • Name: WRW4 TFA
  • Chemical Name: L-Tryptophanamide, L-tryptophyl-L-arginyl-L-tryptophyl-L-tryptophyl-L-tryptophyl
  • CAS Number: 878557-55-2
  • Molecular Formula: C61H65N15O6
  • Molecular Weight: 1104.27000
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2017-06-22 13:15:40
  • Modify Date: 2024-01-10 09:54:24
  • WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide[1].

Name L-Tryptophanamide, L-tryptophyl-L-arginyl-L-tryptophyl-L-tryptophyl-L-tryptophyl
Synonyms NPEC-caged-noradrenalin
Description WRW4, a specific formyl peptide receptor-like 1 (FPRL1) antagonist, inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 μM. WRW4 specifically inhibits the increase in intracellular calcium by the FPRL1 agonists MMK-1, amyloid beta42 (Abeta42) peptide, and F peptide[1].
Related Catalog
In Vitro WRW4 inhibits Abeta42 peptide-induced superoxide generation and chemotactic migration of neutrophils, and also completely inhibits the internalization of Abeta42 peptide in human macrophages. WRW4 specifically blocks ERK phosphorylation downstream of FPRL1 by WKYMVm[1].
References

[1]. Bae YS, et al. Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling. J Immunol. 2004;173(1):607-614.

Molecular Formula C61H65N15O6
Molecular Weight 1104.27000
Exact Mass 1103.52000
PSA 355.46000
LogP 8.65230
Storage condition -20℃