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66722-44-9

66722-44-9 structure
66722-44-9 structure
  • Name: Bisoprolol
  • Chemical Name: bisoprolol
  • CAS Number: 66722-44-9
  • Molecular Formula: C18H31NO4
  • Molecular Weight: 325.443
  • Catalog: API Circulatory system medication Antiarrhythmic drug
  • Create Date: 2018-02-05 08:00:00
  • Modify Date: 2024-01-05 09:35:40
  • Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker. Bisoprolol has little activity on β2-receptor and has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research[1][2].
Name bisoprolol
Synonyms 1-[(1-methylethyl)amino]-3-({4-[({2-[(1-methylethyl)oxy]ethyl}oxy)methyl]phenyl}oxy)propan-2-ol
(±)-1-[p-(2-Isopropoxyethoxymethyl)phenoxy]-3-(isopropylamino)-2-propanol
1-(propan-2-ylamino)-3-(4-{[2-(propan-2-yloxy)ethoxy]methyl}phenoxy)propan-2-ol
Bisoprolol
1-(4-{[2-(1-methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]propan-2-ol
2-Propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-
MFCD00865795
1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol
(±)-1-[[a-(2-Isopropoxyethoxy)-p-tolyl]oxy]-3-(isopropylamino)-2-propanol
1-{4-[(2-Isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)propan-2-ol
1-[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-2-propanol
1-{4-[(2-Isopropoxyethoxy)methyl]phenoxy}-3-(isopropylamino)-2-propanol
2-Propanol, 1-[4-[[2-(1-methylethoxy)ethoxy]methyl]phenoxy]-3-[(1-methylethyl)amino]-
Description Bisoprolol is a potent, selective and orally active β1-adrenergic receptor blocker. Bisoprolol has little activity on β2-receptor and has the potential for hypertension, coronary artery disease and stable ventricular dysfunction research[1][2].
Related Catalog
Target

β1-adrenergic receptor[1]

References

[1]. Jillian G Baker, et al. The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br J Pharmacol. 2005 Feb;144(3):317-22.

[2]. Maria Hoeltzenbein, et al. Pregnancy outcome after first trimester exposure to bisoprolol: an observational cohort study. J Hypertens. 2018 Oct;36(10):2109-2117.
Density 1.0±0.1 g/cm3
Boiling Point 445.0±45.0 °C at 760 mmHg
Molecular Formula C18H31NO4
Molecular Weight 325.443
Flash Point 222.9±28.7 °C
Exact Mass 325.225311
PSA 59.95000
LogP 2.14
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.500

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UB8380000
CHEMICAL NAME :
2-Propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1 -methylethyl)amino)-
CAS REGISTRY NUMBER :
66722-44-9
LAST UPDATED :
199206
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C18-H31-N-O4
MOLECULAR WEIGHT :
325.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
143 ug/kg
TOXIC EFFECTS :
Cardiac - change in rate
REFERENCE :
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990- Volume(issue)/page/year: 9,255,1990
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Hazard Codes Xi
Risk Phrases R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
RTECS UB8380000
HS Code 2922509090
HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Chemsrc provides CAS#:66722-44-9 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 66722-44-9 | Chemsrc address: https://www.chemsrc.com/en/baike/1026719.html

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