Name | Alacepril |
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Synonyms |
1-(d-3-acetylthio-2-methylpropanoyl)-l-prolyl-l-phenylalanine
(S)-N-[1-[3-(acetylthio)-2-methyl-1-oxopropyl]-L-prolyl]-L-phenylalanil L-Phenylalanine,1-[(2S)-3-(acetylthio)-2-methyl-1-oxopropyl]-L-prolyl 1-((S)-3-acetylthio-2-methylpropanoyl)-L-prolyl-L-phenylalanine cetapril 1-[(2S)-3-(acetylthio)-2-methyl-1-oxopropyl]-L-prolyl-L-phenylalanine N-[(S)-3-Acetylthio-2-methylpropanoyl]-L-Pro-L-Phe-OH du1219 Cetapfil (s)-l-phenylalanin 1-[(S)-3-Acetylthio-2-methylpropanoyl]-L-Pro-L-Phe-OH MFCD00869538 |
Description | Alacepril (Cetapril) is an orally active angiotensin converting enzyme (ACE) inhibitor with long lasting antihypertensive effect[1]. |
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Related Catalog | |
In Vivo | The long lasting antihypertensive effect of Alacepril in renal hypertensive rats is confirmed by once daily successive oral administration (1-2 mg/kg/d). In renal hypertensive dogs, Alacepril (3 mg/kg) showed a stable and sustained hypotensive effect, and its duration of action was longer than that of captopril[1]. |
References |
Density | 1.281g/cm3 |
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Boiling Point | 679.1ºC at 760 mmHg |
Molecular Formula | C20H26N2O5S |
Molecular Weight | 406.49600 |
Flash Point | 364.5ºC |
Exact Mass | 406.15600 |
PSA | 129.08000 |
LogP | 2.03410 |
Index of Refraction | 1.581 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Hazard Codes | Xn |
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Risk Phrases | R22:Harmful if swallowed. |
WGK Germany | 3 |
RTECS | UO3516500 |
~99% 74258-86-9 |
Literature: NICOX S.A. Patent: WO2004/106300 A1, 2004 ; Location in patent: Page 65 ; |
~% 74258-86-9 |
Literature: US4248883 A1, ; |
~65% 74258-86-9 |
Literature: Sawayama; Itokawa; Shimada; Doi; Kimura; Nishim ura Chemical and Pharmaceutical Bulletin, 1990 , vol. 38, # 2 p. 529 - 531 |
~% 74258-86-9 |
Literature: Chemical and Pharmaceutical Bulletin, , vol. 38, # 2 p. 529 - 531 |
~% 74258-86-9 |
Literature: Chemical and Pharmaceutical Bulletin, , vol. 38, # 2 p. 529 - 531 |
~% 74258-86-9 |
Literature: Chemical and Pharmaceutical Bulletin, , vol. 38, # 2 p. 529 - 531 |
~% 74258-86-9 |
Literature: Chemical and Pharmaceutical Bulletin, , vol. 38, # 2 p. 529 - 531 |
Precursor 7 | |
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DownStream 0 |