Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-Pyrrolidinepropanol, a-cyclohexyl-a-phenyl-
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77-37-2

77-37-2 structure

Name: 1-Pyrrolidinepropanol, a-cyclohexyl-a-phenyl-
Chemical Name: procyclidine
CAS Number: 77-37-2
Molecular Formula: C₁₉H₂₉NO
Molecular Weight: 287.44000
Catalog: API Nervous system medication Anti-shock palsy
Create Date: 2018-03-19 08:00:00
Modify Date: 2024-01-10 13:05:51
Procyclidine (Tricyclamol; (±)-Procyclidine), an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine can be used in studies of Parkinson's disease and related psychiatric disorders such as Soman-induced epilepsy[1][2].

Name	procyclidine
Synonyms	Kemadrine Arpicolin Procyklidin Spamol 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-yl-propan-1-ol 1-Cyclohexyl-3-pyrrolidino-1-phenyl-propan-1-ol Lergine Elorine 1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol Triciclidina tricyclamol Osnervan 1-Cyclohexyl-1-phenyl-3-pyrrolidino-propan-1-ol

Description	Procyclidine (Tricyclamol; (±)-Procyclidine), an anticholinergic agent, is a muscarinic receptor antagonist that also has the properties of an N-methyl-D-aspartate (NMDA) antagonist. Procyclidine can be used in studies of Parkinson's disease and related psychiatric disorders such as Soman-induced epilepsy[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Signaling Pathways >> Neuronal Signaling >> mAChR Signaling Pathways >> GPCR/G Protein >> mAChR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vivo	Procyclidine (subcutaneous injection, 0.3-6.0 mg/kg) in combination with physostigmine (PhS) increases protection in a dose-dependent manner in rats and guinea pigs infected with soman and can prevent seizures altogether[1]. Animal Model: Male Sprague-Dawley rats, Dunkin-Hartley male guinea pigs[1] Dosage: 0.3-6.0 mg/kg Administration: Subcutaneous injection; once Result: Increased protection, resulting in 1.92, 2.24, 3.95 and 5.07 fold in rats, 3.00, 3.25, 4.50 and 4.70 fold in guinea pigs at the doses of 0.3, 1.0, 3.0 or 6.0 mg/kg, respectively. Protected the neurological integrity of the brain and prevented Soman-induced severe brain damage in the hippocampus, cortex, amygdala and thalamus.
References	[1]. Yun-Bae Kim, et al. Effects of combinational prophylactics composed of physostigmine and procyclidine on soman-induced lethality, seizures and brain injuries. Environ Toxicol Pharmacol. 2002 Jan;11(1):15-21. [2]. Ulrich Ettinger, et al. Effects of procyclidine on eye movements in schizophrenia. Neuropsychopharmacology. 2003 Dec;28(12):2199-208.

Density	1.057 g/cm3
Boiling Point	433.5ºC at 760 mmHg
Melting Point	85.5-86.5°
Molecular Formula	C₁₉H₂₉NO
Molecular Weight	287.44000
Flash Point	205.7ºC
Exact Mass	287.22500
PSA	23.47000
LogP	3.87830
Index of Refraction	1.554

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY1925000

CHEMICAL NAME :: 1-Pyrrolidinepropanol, alpha-cyclohexyl-alpha-phenyl-

CAS REGISTRY NUMBER :: 77-37-2

BEILSTEIN REFERENCE NO. :: 0088563

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C19-H29-N-O

MOLECULAR WEIGHT :: 287.49

WISWESSER LINE NOTATION :: T5NTJ A2XQR&- AL6TJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 131 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,291,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,291,1972

6072-22-6

77-37-2

Literature: Adamson et al. Journal of the Chemical Society, 1951 , p. 52,58

6317-35-7

77-37-2

Literature: Ratouis; Combes Bulletin de la Societe Chimique de France, 1959 , p. 576,578

94-39-3

931-50-0

77-37-2

Literature: Adamson et al. Journal of the Chemical Society, 1951 , p. 52,58

Precursor 4
6072-22-6 6317-35-7 94-39-3 931-50-0
DownStream 2
32381-62-7 32381-63-8

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