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61966-08-3

61966-08-3 structure
61966-08-3 structure
  • Name: Phosphate Salt of Tricyclic Nucleoside
  • Chemical Name: triciribine phosphate
  • CAS Number: 61966-08-3
  • Molecular Formula: C13H17N6O7P
  • Molecular Weight: 400.28
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel ATP Synthase
  • Create Date: 2018-10-17 17:38:57
  • Modify Date: 2024-01-03 13:56:37
  • Triciribine phosphate (TCN-P) inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate also inhibits  IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity[1].
Name triciribine phosphate
Synonyms 5-Methyl-1-(5-O-phosphono-b-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine
5-Methyl-1-(5-O-phosphono-β-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine
Pentaazaacenaphthylene-5' phosphate ester
3-Amino-1,5-dihydro-5-methyl-1-b-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylene 5'-(Dihydrogen Phosphate)
Phosphate Salt of Tricyclic Nucleoside
Triciribine phosphate (USAN)
1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-(5-O-phosphono-β-D-ribofuranosyl)-
VQD-002
TCN-P
Description Triciribine phosphate (TCN-P) inhibits amidophosphoribosyltransferase by an allosteric mechanism which affects the first committed step of de novo purine biosynthesis. Triciribine phosphate also inhibits  IMP dehydrogenase which is the first committed step of guanosine nucleotide synthesis. Tricilibine phosphate does not affect ligase activity[1].
Related Catalog
References

[1]. E C Moore, Inhibition of two enzymes in de novo purine nucleotide synthesis by triciribine phosphate (TCN-P). Biochem Pharmacol. 1989, 38, 22.  

Density 2.2±0.1 g/cm3
Boiling Point 832.8±75.0 °C at 760 mmHg
Molecular Formula C13H17N6O7P
Molecular Weight 400.28
Flash Point 457.4±37.1 °C
Exact Mass 400.089630
PSA 200.81000
LogP -2.83
Vapour Pressure 0.0±3.2 mmHg at 25°C
Index of Refraction 1.925

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RY8450000
CHEMICAL NAME :
1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-(5-O-phosphono-beta-D- ribofuranosyl)-
CAS REGISTRY NUMBER :
61966-08-3
LAST UPDATED :
198605
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C13-H17-N6-O7-P
MOLECULAR WEIGHT :
400.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
193 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
109 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

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title: CAS No. 61966-08-3 | Chemsrc address: https://www.chemsrc.com/en/baike/1031688.html

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