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52806-53-8

52806-53-8 structure
52806-53-8 structure
  • Name: 2-Hydroxyflutamide
  • Chemical Name: Hydroxy Flutamide
  • CAS Number: 52806-53-8
  • Molecular Formula: C11H11F3N2O4
  • Molecular Weight: 292.211
  • Create Date: 2018-03-26 08:00:00
  • Modify Date: 2024-01-02 14:26:20
  • Hydroxyflutamide (HF), an active metabolite of Flutamide, is a potent androgen receptor antagonist (IC50=700 nM). Hydroxyflutamide can be used for the research of prostate cancer[1][2].
Name Hydroxy Flutamide
Synonyms 2-hydroxy Flutamide
2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
Propanamide, 2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-
2-Hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)propanamide
Hydroxyflutamide
2-Hydroxy-flutamide
Description Hydroxyflutamide (HF), an active metabolite of Flutamide, is a potent androgen receptor antagonist (IC50=700 nM). Hydroxyflutamide can be used for the research of prostate cancer[1][2].
Related Catalog
Target

IC50: 700 nM (androgen receptor)[1]

References

[1]. Furr BJ, et, al. Casodex: preclinical studies and controversies. Ann N Y Acad Sci. 1995 Jun 12;761:79-96.

[2]. Liu HL, et, al. A Molecular Modeling Study of the Hydroxyflutamide Resistance Mechanism Induced by Androgen Receptor Mutations. Int J Mol Sci. 2017 Aug 23;18(9):1823.
Density 1.5±0.1 g/cm3
Boiling Point 443.8±45.0 °C at 760 mmHg
Melting Point 125-130℃
Molecular Formula C11H11F3N2O4
Molecular Weight 292.211
Flash Point 222.2±28.7 °C
Exact Mass 292.067078
PSA 95.15000
LogP 3.16
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.546

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TX1466250
CHEMICAL NAME :
Propanamide, 2-hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phen yl)-
CAS REGISTRY NUMBER :
52806-53-8
LAST UPDATED :
199706
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C11-H11-F3-O2-N4
MOLECULAR WEIGHT :
288.26

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
60 mg/kg/6D-I
TOXIC EFFECTS :
Endocrine - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
REFERENCE :
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981- Volume(issue)/page/year: 1,297,1981 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6 gm/kg
SEX/DURATION :
female 11-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - other effects on male
REFERENCE :
CJPPA3 Canadian Journal of Physiology and Pharmacology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.42- 1964- Volume(issue)/page/year: 73,1582,1995
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2400 mg/kg
SEX/DURATION :
female 15-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands Reproductive - Paternal Effects - other effects on male
REFERENCE :
CJPPA3 Canadian Journal of Physiology and Pharmacology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.42- 1964- Volume(issue)/page/year: 73,1582,1995
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Hazard Codes Xi
RIDADR NONH for all modes of transport
RTECS TX1466250
HS Code 2924299090
HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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title: CAS No. 52806-53-8 | Chemsrc address: https://www.chemsrc.com/en/baike/1032907.html

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