Name | tributyrin |
---|---|
Synonyms |
Tributyrinine
MFCD00009392 1,2,3-Propanetriyl tributanoate Butanoic acid, 1,2,3-propanetriyl ester Propane-1,2,3-triyl tributanoate Tributyroin glyceryl tributyrate Tributin Butyryl triglyceride Glycerol tributyrate 2,3-di(butanoyloxy)propyl butanoate EINECS 200-451-5 glycerol tributanoate 1,2,3-Tributyrylglycerol Butanoic acid,1,2,3-propanetriyl ester butyrin TRIBUTYRIN |
Description | Tributyrin (Glyceryl tributyrate), a neutral short-chain fatty acid triglyceride, is a stable and rapidly absorbed prodrug of Butyric Acid. Tributyrin diffuses through biological membranes and is metabolized by intracellular lipases, releasing effective butyrate directly into the cell in vivo. Tributyrin has potent antiproliferative, proapoptotic and differentiation-inducing effects[1]. |
---|---|
Related Catalog | |
References |
Density | 1.1±0.1 g/cm3 |
---|---|
Boiling Point | 307.5±0.0 °C at 760 mmHg |
Melting Point | -75 °C |
Molecular Formula | C15H26O6 |
Molecular Weight | 302.363 |
Flash Point | 173.9±0.0 °C |
Exact Mass | 302.172943 |
PSA | 78.90000 |
LogP | 2.95 |
Vapour Pressure | 0.0±0.6 mmHg at 25°C |
Index of Refraction | 1.448 |
Storage condition | Store at RT. |
Stability | Stable. Incompatible with strong oxidizing agents. |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Personal Protective Equipment | Eyeshields;Gloves |
---|---|
Hazard Codes | Xi |
Safety Phrases | S24/25 |
RIDADR | NONH for all modes of transport |
WGK Germany | 1 |
RTECS | ET7350000 |
HS Code | 2915900090 |
~92% 60-01-5 |
Literature: Prager, Rolf H.; Yurui, Zhang Australian Journal of Chemistry, 1989 , vol. 42, # 6 p. 1003 - 1005 |
~95% 60-01-5 |
Literature: Akthelia Pharmaceuticals Patent: US2011/118217 A1, 2011 ; |
~% 60-01-5 |
Literature: Nudelman, Abraham; Ruse, Margaretta; Aviram, Adina; Rabizadeh, Ester; Shaklai, Matityahu; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 687 - 694 |
~% 60-01-5 |
Literature: Newman; Trikojus; Harker Journal and Proceedings of the Royal Society of New South Wales, vol. 59, p. 296 Chem. Zentralbl., 1927 , vol. 98, # II p. 802 |
~% 60-01-5 |
Literature: Partheil; v.Velsen Archiv der Pharmazie (Weinheim, Germany), 1900 , vol. 238, p. 267 |
~% 60-01-5 |
Literature: Newman; Trikojus; Harker Journal and Proceedings of the Royal Society of New South Wales, vol. 59, p. 298 Chem. Zentralbl., 1927 , vol. 98, # II p. 802 |
~% 60-01-5 |
Literature: Guth Z.B., 1903 , vol. 44, p. 95 |
Precursor 7 | |
---|---|
DownStream 9 | |
HS Code | 2915900090 |
---|---|
Summary | 2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0% |