Name | Zinterol hydrochloride |
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Synonyms | N-[2-hydroxy-5-[1-hydroxy-2-[(2-methyl-1-phenylpropan-2-yl)amino]ethyl]phenyl]methanesulfonamide,hydrochloride |
Description | Zinterol hydrochloride (MJ 9184 hydrochloride) is a potent and selective β2-adrenoceptor agonist[1]. Zinterol hydrochloride increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM[2]. Zinterol hydrochloride induces ventricular arrhythmias in conscious heart failure rabbits[3]. |
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Related Catalog | |
Target |
β2-adrenoceptor[1] |
In Vivo | Zinterol (2.5 μg/kg i.v. bolus over 5 s) leads to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of ventricular tachycardia (VT) in heart failure (HF) rabbits. Zinterol at a lower dose (1 μg/kg i.v, n=4) does not induce ventricular arrhythmias in HF rabbits[3]. Animal Model: In New Zealand White HF rabbits of either sex[3] Dosage: 1.0 or 2.5 μg/kg Administration: Intravenous bolus administration; over 5 seconds Result: 2.5 μg/kg did not significantly alter heart rate or mean arterial blood pressure in either control or HF rabbits. 2.5 μg/kg led to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of VT (up to 13 beats long) in 4 of 6 HF rabbits (vs 0 of 5 controls, p<0.01). 1 μg/kg did not induce ventricular arrhythmias in HF rabbits. |
References |
Boiling Point | 574.3ºC at 760 mmHg |
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Molecular Formula | C19H27ClN2O4S |
Molecular Weight | 414.94700 |
Flash Point | 301.1ºC |
Exact Mass | 414.13800 |
PSA | 107.04000 |
LogP | 4.75470 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
|
Symbol |
GHS07 |
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Signal Word | Warning |
Hazard Statements | H319 |
Precautionary Statements | P305 + P351 + P338 |
Hazard Codes | Xi |
RIDADR | NONH for all modes of transport |