118292-34-5

118292-34-5 structure

Name: Duocarmycin A
Chemical Name: duocarmycin a
CAS Number: 118292-34-5
Molecular Formula: C₂₆H₂₅N₃O₈
Molecular Weight: 507.49200
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
Create Date: 2016-09-28 18:28:36
Modify Date: 2024-01-05 15:39:46
Duocarmycin A, which is one of well-known antitumor antibiotics, efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels[1].

Name	duocarmycin a
Synonyms	(+)-Dunnione (+)-duocarmycin A

Description	Duocarmycin A, which is one of well-known antitumor antibiotics, efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin Signaling Pathways >> Apoptosis >> Caspase
Target	Procaspase-3 Caspase-9
References	[1]. Hirota M, et al. Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells. Int J Biochem Cell Biol. 2007;39(5):988-96.