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  • DC Chemicals Limited
  • China
  • Product Name: 5-Ph-IAA
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

168649-23-8

168649-23-8 structure
168649-23-8 structure
  • Name: 5-Ph-IAA
  • Chemical Name: 2-(5-phenyl-1H-indol-3-yl)acetic acid
  • CAS Number: 168649-23-8
  • Molecular Formula: C16H13NO2
  • Molecular Weight: 251.28000
  • Catalog: Signaling Pathways Others Others
  • Create Date: 2017-06-26 05:01:34
  • Modify Date: 2024-01-12 11:38:35
  • 5-Ph-IAA is a derivative of IAA. 5-Ph-IAA, a ligand, establishes the auxin-inducible degron 2 (AID2) system together with an OsTIR1 (F74G) mutant. AID2 induces rapid and efficient depletion of mAID-fused proteins to study protein function in living cells, causing tumor suppression[1].

Name 2-(5-phenyl-1H-indol-3-yl)acetic acid
Synonyms 1H-Indole-3-acetic acid,5-phenyl
Description 5-Ph-IAA is a derivative of IAA. 5-Ph-IAA, a ligand, establishes the auxin-inducible degron 2 (AID2) system together with an OsTIR1 (F74G) mutant. AID2 induces rapid and efficient depletion of mAID-fused proteins to study protein function in living cells, causing tumor suppression[1].
Related Catalog
In Vitro HCT116 cells constitutively expressing OsTIR1(F74G) are exposed to 5-Ph-IAA (1 µM; 6 hours), leading to DHC1-mAC degradation, which means the AID2 system better than the original AID system in generating conditional mutant cell lines[1]. Western Blot Analysis[1] Cell Line: HCT116 cells Concentration: 1 µM Incubation Time: 6 hours Result: Depleted DHC1-mAC efficiently in HCT116 cells constitutively expressing OsTIR1(F74G).
In Vivo 5-Ph-IAA (0-10 mg/kg; intraperitoneally injection; every day; 7 days), used for the AID2 system ,is sufficient to deplete mAID-BRD4 and TOP2A-mAC, leading to tumour suppression[1]. Animal Model: Balb/c-nu female mice (7 weeks old; 16–20 g ) bearing mAID-BRD4 and TOP2A-mAC xenograft tumours cells[1] Dosage: 0 mg/kg, 1 mg/kg, 3 mg/kg and 10 mg/kg Administration: Intraperitoneally injection; every day; 7 days Result: Displayed significant tumour suppression of mAID-BRD4 xenografts and TOP2A-mAC xenografts.
References

[1]. Aisha Yesbolatova, et al. The auxin-inducible degron 2 technology provides sharp degradation control in yeast, mammalian cells, and mice. Nat Commun. 2020 Nov 11;11(1):5701.

Molecular Formula C16H13NO2
Molecular Weight 251.28000
Exact Mass 251.09500
PSA 53.09000
LogP 3.46200