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52214-84-3

52214-84-3 structure
52214-84-3 structure
  • Name: Ciprofibrate
  • Chemical Name: ciprofibrate
  • CAS Number: 52214-84-3
  • Molecular Formula: C13H14Cl2O3
  • Molecular Weight: 289.155
  • Catalog: API Circulatory system medication Regulating blood lipids
  • Create Date: 2018-04-06 08:00:00
  • Modify Date: 2024-01-02 08:59:35
  • Ciprofibrate is a peroxisome proliferator-activated receptor agonist.Target: PPARCiprofibrate is a hypolipidemic compound that can induce proliferation of peroxisomes in liver cells of rats. Known to be a PPARα (peroxisome proliferator-activated receptor α) agonist [1, 2].
Name ciprofibrate
Synonyms 2-[p-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid
Ciprofibrate
2-[p-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid,Ciprofibrate
EINECS 257-744-6
MFCD00467135
2-(4-(2,2-Dichlorocyclopropyl)phenoxy)-2-methylpropanoic acid
2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropionic Acid
UNII:F8252JGO9S
2-[4-(2,2-dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid
Description Ciprofibrate is a peroxisome proliferator-activated receptor agonist.Target: PPARCiprofibrate is a hypolipidemic compound that can induce proliferation of peroxisomes in liver cells of rats. Known to be a PPARα (peroxisome proliferator-activated receptor α) agonist [1, 2].
Related Catalog
Target

PPARα

References

[1]. Passilly, P., et al., Phosphorylation of peroxisome proliferator-activated receptor alpha in rat Fao cells and stimulation by ciprofibrate. Biochem Pharmacol, 1999. 58(6): p. 1001-8.

[2]. Clemencet, M.C., et al., Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate. Cancer Lett, 2005. 222(2): p. 217-26.
Density 1.4±0.1 g/cm3
Boiling Point 424.9±45.0 °C at 760 mmHg
Melting Point 114 - 118ºC
Molecular Formula C13H14Cl2O3
Molecular Weight 289.155
Flash Point 210.7±28.7 °C
Exact Mass 288.032013
PSA 46.53000
LogP 2.87
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.579
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UF0880000
CHEMICAL NAME :
Propionic acid, 2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methyl-
CAS REGISTRY NUMBER :
52214-84-3
LAST UPDATED :
199706
DATA ITEMS CITED :
14
MOLECULAR FORMULA :
C13-H14-Cl2-O3
MOLECULAR WEIGHT :
289.17
WISWESSER LINE NOTATION :
L3TJ AG AG BR DOX1&1&VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3640 mg/kg/26W-I
TOXIC EFFECTS :
Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other oxidoreductases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
105 mg/kg/7D-C
TOXIC EFFECTS :
Liver - other changes Liver - changes in liver weight Biochemical - Metabolism (Intermediary) - other proteins
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 mg/kg/5D-I
TOXIC EFFECTS :
Liver - other changes Kidney, Ureter, Bladder - other changes
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Primate - monkey
DOSE/DURATION :
14560 mg/kg/26W-I
TOXIC EFFECTS :
Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - dehydrogenases
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6390 mg/kg/60W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Lungs, Thorax, or Respiration - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
6720 mg/kg/64W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
7300 mg/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
280 mg/kg
SEX/DURATION :
female 15-21 day(s) after conception lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)
TYPE OF TEST :
Morphological transformation
TYPE OF TEST :
DNA damage
TYPE OF TEST :
Unscheduled DNA synthesis

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - rat Liver
DOSE/DURATION :
100 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 286,135,1993
Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H350
Precautionary Statements P201-P280-P308 + P313
Personal Protective Equipment Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes T:Toxic
Risk Phrases R45
Safety Phrases S53-S22-S36/37/39-S45
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS UF0880000
HS Code 2918990090
52179-26-7 structure

52179-26-7

~%

52214-84-3 structure

52214-84-3

Literature: Sterling Drug Inc. Patent: US3948973 A1, 1976 ;
Precursor  1

DownStream  0

HS Code 2918990090
Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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