3133-16-2

3133-16-2 structure

Name: 4-Octyl Itaconate
Chemical Name: 3-octan-4-yloxycarbonylbut-3-enoate
CAS Number: 3133-16-2
Molecular Formula: C₁₃H₂₂O₄
Molecular Weight: 242.31
Catalog: Signaling Pathways NF-κB Keap1-Nrf2
Create Date: 2016-12-31 07:32:06
Modify Date: 2024-01-03 12:36:38
4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.

Name	3-octan-4-yloxycarbonylbut-3-enoate
Synonyms	Butanedioic acid,methylene-,4-octyl ester 4-Octyl Itaconate

Description	4-Octyl Itaconate is a cell-permeable Itaconate derivative. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
Related Catalog	Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Inflammation/Immunology
Target	Nrf2[1]
In Vivo	4-Octyl Itaconate (OI) is a cell-permeable itaconate derivative. 4-Octyl Itaconate is protective against lipopolysaccharide-induced lethality in vivo and decreases cytokine production[1].
References	[1]. Mills EL, et al. Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1. Nature. 2018 Apr 5;556(7699):113-117.