446254-47-3

446254-47-3 structure

Name: phosphoric acid,pyridine-3,4-diamine
Chemical Name: phosphoric acid,pyridine-3,4-diamine
CAS Number: 446254-47-3
Molecular Formula: C₅H₁₀N₃O₄P
Molecular Weight: 207.12400
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2017-04-21 19:20:36
Modify Date: 2024-01-16 22:07:38
Amifampridine (3,4-Diaminopyridine) phosphate is an orally active potassium channel blocker (PCB), can block presynaptic potassium channels[1]. Amifampridine phosphate can be used in Lambert-Eaton myasthenic syndrome (LEMS) research[1].

Name	phosphoric acid,pyridine-3,4-diamine
Synonyms	Amifampridine phosphate 3,4-Diaminopyridine phosphate UNII-8HF8FIN815 Firdapse Zenas

Description	Amifampridine (3,4-Diaminopyridine) phosphate is an orally active potassium channel blocker (PCB), can block presynaptic potassium channels[1]. Amifampridine phosphate can be used in Lambert-Eaton myasthenic syndrome (LEMS) research[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
In Vivo	Amifampridine phosphate treatment (Intravenous injection; 2.5 mg/kg; once) shows 1 hour plasma half-life[2]. Amifampridine phosphate treatment (Oral administration; 10 mg/kg; once) shows plasma concentrations spike[2]. Animal Model: Mice[2] Dosage: 2.5 mg/kg Administration: Intravenous injection; 2.5 mg/kg; once Result: Had a plasma half-life of about 1 hour. Animal Model: Mice[2] Dosage: 10 mg/kg Administration: Oral administration; 10 mg/kg; once Result: Exhibited a rapid spike in plasma concentrations.
References	[1]. Maarten J Titulaer, et al. Lambert-Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies. Lancet Neurol. 2011 Dec;10(12):1098-107. [2]. T L Harris, et al. Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication. Chem Commun (Camb). 2016 Mar 18;52(22):4187-90.

54-96-6

446254-47-3

Literature: Guyon, Francois; Pradeau, Dominique; Le Hoang, My Dung; Houri, Jean-Jacques Patent: US2004/106651 A1, 2004 ; Location in patent: Page 3 ;

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54-96-6
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