6452-71-7

6452-71-7 structure

Name: oxprenolol
Chemical Name: 1-(2-allyloxyphenoxy)-2-hydroxy-3-isopropylaminopropane
CAS Number: 6452-71-7
Molecular Formula: C₁₅H₂₃NO₃
Molecular Weight: 265.34800
Catalog: API Circulatory system medication Antiarrhythmic drug
Create Date: 2018-06-21 13:40:28
Modify Date: 2024-01-11 11:28:47
Oxprenolol (Ba 39089 free base) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle[1].

Name	1-(2-allyloxyphenoxy)-2-hydroxy-3-isopropylaminopropane
Synonyms	2-PROPANOL,1-[(1-METHYLETHYL)AMINO]-3-[2-(2-PROPEN-1-YLOXY)PHENOXY]- Oxprenolol

Description	Oxprenolol (Ba 39089 free base) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor
Target	β-adrenoceptor:7.10 nM (Ki)
In Vitro	Oxprenolol is lipophilic[3]. Oxprenolol shows permeability rate constant of 1.54 ± 1.54×10-3 cm/h across abdominal human skin[3].
In Vivo	Oxprenolol (200 mg/kg/day; p.o.; daily for 3 weeks) produces effective beta-blockade together with peak plasma drug levels within the normal clinical range[2]. Animal Model: Male rats (230 to 300 g body wt) of the Wistar strain[2] Dosage: 200 mg/kg Administration: Administered orally; daily for 3 weeks Result: This dosage produced effective beta-blockade.
References	[1]. T Nagatomo, et al. Binding Characteristics of ³H-dihydroalprenolol to Beta-Adrenoceptors of Rat Heart Treated With Neuraminidase. Jpn J Pharmacol. 1983 Aug;33(4):851-7. [2]. A S Manning, et al. Abrupt Withdrawal of Chronic Beta-Blockade: Adaptive Changes in Cyclic AMP and Contractility. J Mol Cell Cardiol. 1981 Nov;13(11):999-1009. [3]. Modamio P, et al. A comparative in vitro study of percutaneous penetration of β-blockers in human skin. International journal of pharmaceutics, 2000, 194(2): 249-259.