523-80-8

523-80-8 structure

Name: Apiole (parsley)
Chemical Name: 4,7-dimethoxy-5-prop-2-enyl-1,3-benzodioxole
CAS Number: 523-80-8
Molecular Formula: C₁₂H₁₄O₄
Molecular Weight: 222.24
Catalog: Biochemical Plant extracts
Create Date: 2018-03-15 08:00:00
Modify Date: 2024-01-04 08:59:30
Apiole is an anti-tumor agent that induces apoptosis and inhibits human colon cancer cells by inducing G0/G1 cell cycle arrest. Apiole also significantly inhibited colon tumor development in an in vivo mouse xenograft model[1][2].

Name	4,7-dimethoxy-5-prop-2-enyl-1,3-benzodioxole
Synonyms	Apiole (parsley) Apiol 1-allyl-2,5-dimethoxy-3,4-methylenedioxybenzene Petersiliencampher 3,6-dimethoxy-4,5-methylenedioxy-allylbenzene 1-allyl-3,4-methylenedioxy-2,5-dimethoxybenzene Apiole Apioline 5-Allyl-4,7-dimethoxy-1,3-benzodioxole Parsley apiol 1,3-Benzodioxole,4,7-dimethoxy-5-(2-propenyl) Parsley apiole Parsley camphor

Description	Apiole is an anti-tumor agent that induces apoptosis and inhibits human colon cancer cells by inducing G0/G1 cell cycle arrest. Apiole also significantly inhibited colon tumor development in an in vivo mouse xenograft model[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
References	[1]. Wu KH, et al. Study of the antitumor mechanisms of apiole derivatives (AP-02) from Petroselinum crispum through induction of G0/G1 phase cell cycle arrest in human COLO 205 cancer cells. BMC Complement Altern Med. 2019 Jul 27;19(1):188. [2]. Wei PL, et al. The in vivo antitumor effects on human COLO 205 cancer cells of the 4,7-dimethoxy-5-(2-propen-1-yl)-1,3-benzodioxole (apiole) derivative of 5-substituted 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1) isolated from the fruiting body of Antrodia camphorate. J Cancer Res Ther. 2012 Oct-Dec;8(4):532-6.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TOXIC EFFECTS :: Peripheral Nerve and Sensation - spastic paralysis with or without sensory change Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - other changes

REFERENCE :: CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980- Volume(issue)/page/year: 5,1613,1984

23731-75-1

4873-09-0

~67%

523-80-8

Literature: Tsukada, Naofumi; Yagura, Yasushige; Sato, Tetsuo; Inoue, Yoshio Synlett, 2003 , # 10 p. 1431 - 1434