3475-39-6
3475-39-6 structure
- Name: 1,1,3-Tribromoacetone
- Chemical Name: 1,1,3-tribromopropan-2-one
- CAS Number: 3475-39-6
- Molecular Formula: C3H3Br3O
- Molecular Weight: 294.767
- Catalog: Signaling Pathways Others Others
- Create Date: 2018-07-14 19:44:28
- Modify Date: 2024-01-02 17:13:52
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1,1,3-Tribromoacetone is an impurity of methotrexate[1]. Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1].
| Name | 1,1,3-tribromopropan-2-one |
|---|---|
| Synonyms |
1,1,3-Tribromoacetone
1,1,3-tribromopropanone 1,1,3-Tribrom-aceton 1,1,3-tribromo-propan-2-one 1,3-Tribromoacetone 2-Propanone, 1,1,3-tribromo- 1,1,3-tribromo-2-propanone 2-Propanone,1,3-tribromo |
| Description | 1,1,3-Tribromoacetone is an impurity of methotrexate[1]. Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1]. |
|---|---|
| Related Catalog | |
| In Vivo | Methotrexate (Amethopterin) reduces thymus and spleen indices of mice. Methotrexate markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice[2]. Methotrexate (MTX) (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity[3]. |
| References |
| Density | 2.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 266.2±25.0 °C at 760 mmHg |
| Molecular Formula | C3H3Br3O |
| Molecular Weight | 294.767 |
| Flash Point | 115.1±9.7 °C |
| Exact Mass | 291.773376 |
| PSA | 17.07000 |
| LogP | 3.25 |
| Vapour Pressure | 0.0±0.5 mmHg at 25°C |
| Index of Refraction | 1.595 |
| HS Code | 2914700090 |
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| Precursor 10 | |
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| DownStream 5 | |
| HS Code | 2914700090 |
|---|---|
| Summary | HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0% |