524-81-2

524-81-2 structure

Name: Mebhydrolin
Chemical Name: 5-benzyl-2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole
CAS Number: 524-81-2
Molecular Formula: C₁₉H₂₀N₂
Molecular Weight: 276.37600
Catalog: Signaling Pathways GPCR/G Protein Histamine Receptor
Create Date: 2018-05-23 08:00:00
Modify Date: 2024-01-07 11:52:30
Mebhydrolin is a specific histamine H1 receptor antagonist.

Name	5-benzyl-2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indole
Synonyms	Mebhydrolin 5-Benzyl-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indol Mebhydrolinum [INN-Latin] Mebhydroline 5-Benzyl-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole 5-Benzyl-2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol 9-benzyl-3-methyl-1,2,3,4-tetrahydro-3-carboline 3-methyl-9-benzyl-1,2,3,4-tetrahydrocarboline Mebhydroline [INN-French] Mebhidrolina [INN-Spanish] EINECS 208-364-4

Description	Mebhydrolin is a specific histamine H1 receptor antagonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology
Target	Histamine H1-receptor[1]
In Vitro	Mebhydrolin is a specific histamine H1-receptor antagonist with minimal sedative properties and comparing it with the effects of chlorpromazine, the archetypical phenothiazine[1]. Mebhydrolin exerts an antihistaminic effect over the period of the ethanol interaction study[2].
References	[1]. O'Neill PA, et al. Chlorpromazine-a specific effect on breathlessness? Br J Clin Pharmacol. 1985 Jun;19(6):793-7. [2]. Franks HM, et al. Interaction between ethanol and antihistamines: 3. Mebhydrolin. Med J Aust. 1981 Oct 31;2(9):477-9.

Density	1.12 g/cm3
Boiling Point	856.1ºC at 760 mmHg
Molecular Formula	C₁₉H₂₀N₂
Molecular Weight	276.37600
Flash Point	471.6ºC
Exact Mass	276.16300
PSA	8.17000
LogP	3.61540
Index of Refraction	1.633
Storage condition	2-8℃

100-44-7

524-81-2

Literature: Yutilov; Smolyar; Volchkov Pharmaceutical Chemistry Journal, 2000 , vol. 34, # 12 p. 661 - 662

115191-20-3

524-81-2

Literature: Yutilov; Smolyar; Volchkov Pharmaceutical Chemistry Journal, 2000 , vol. 34, # 12 p. 661 - 662

1445-73-4

614-31-3

524-81-2

Literature: Farbenfabr. Bayer Patent: DE930444 , 1951 ; Full Text Show Details Schenley Ind. Patent: US2786059 , 1954 ; Full Text Show Details Hoerlein Chemische Berichte, 1954 , vol. 87, p. 463,467, 470

Precursor 4
100-44-7 115191-20-3 1445-73-4 614-31-3
DownStream 0

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