- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: SA 4503 dihydrochloride
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: SA 4503 dihydrochloride
- Price: ￥4896.0/50mg ￥2576.0/25mg ￥736.0/5mg ￥1156.0/10mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: SA4503 2HCl
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Stocking Period: 1 Day
- Contact: Tony Lai
- DC Chemicals Limited
- China
- Product Name: SA4503 2HCl
- Price: $500.0/100mg $850.0/250mg $1600.0/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
165377-44-6
165377-44-6 structure
- Name: SA 4503 dihydrochloride
- Chemical Name: 1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
- CAS Number: 165377-44-6
- Molecular Formula: C23H34Cl2N2O2
- Molecular Weight: 441.434
- Catalog: Signaling Pathways GPCR/G Protein Sigma Receptor
- Create Date: 2016-10-22 18:42:36
- Modify Date: 2024-01-05 17:24:01
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Cutamesine dihydrochloride (SA4503 dihydrochloride) is a potent Sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes.
| Name | 1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride |
|---|---|
| Synonyms |
1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine,dihydrochloride
1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazinedihydrochloride Piperazine, 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)-, hydrochloride (1:2) 1-[2-(3,4-Dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine dihydrochloride SA-4503 SA4503 2HCl SA4503 (dihydrochloride) |
| Description | Cutamesine dihydrochloride (SA4503 dihydrochloride) is a potent Sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes. |
|---|---|
| Related Catalog | |
| Target |
IC50: 17.4 nM (σ1receptor, guinea pig brain membranes)[1] |
| In Vitro | The sigma receptor might be involved in several diseases in the central nervous system. Cutamesine, a potent σ1receptor agonist, has 103-fold higher affinity for σ1 (IC50=17.4 nM) than σ2 (IC50=1,784 nM) sites in guinea pig brain membranes. Cutamesine is 14-fold selective for σ1 (Ki=4.6 nM) over σ2 (Ki=63.1 nM) sites in guinea pig brain homogenates[1]. Cutamesine protects motor neuron NSC34 cells against superoxide dismutase 1 and serum free neurotoxicity. It upregulates the phosphorylation levels of Akt and extracellular signal-regulated kinase (ERK) 1/2[2]. Cutamesine reduces the activation of the MAPK/ERK pathway and down-regulated the ionotropic glutamate receptor, GluR1[3]. |
| In Vivo | Cutamesine extends the survival time in the SOD1G93A mice[2]. |
| Cell Assay | The NSC34 cells are seeded at a density of 7000 cells per well into 96-well plates with D-MEM and transfected using Lipofectamine 2000 mixed with 2 μg /mL of plasmid vector in D-MEM for 6 h. After 6 h, the cell-culture medium is replaced with fresh D-MEM and culture and allowed to proceed for a further 42 h. The cells are then transferred to serum-free D-MEM and immediately treated with Cutamesine at a final concentration of 1, 3, or 10 nM[2]. |
| Animal Admin | Mice: Transgenic female mice overexpressing mutated human SOD1G93A are used in the study. Cutamesine is dissolved in saline and subcutaneously administered at a dose of 1 mg/kg once daily to 5-week-old SOD1G93A mice to the time of death. In a control group, vehicle (saline) is subcutaneously administered at 10 ml/kg[2]. |
| References |
| Boiling Point | 499.2ºC at 760 mmHg |
|---|---|
| Molecular Formula | C23H34Cl2N2O2 |
| Molecular Weight | 441.434 |
| Flash Point | 137.3ºC |
| Exact Mass | 440.199738 |
| PSA | 24.94000 |
| LogP | 4.97650 |
| Vapour Pressure | 4.25E-10mmHg at 25°C |
| HS Code | 2933599090 |
|---|
| HS Code | 2933599090 |
|---|---|
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |