95153-31-4

95153-31-4 structure

Name: Perindoprilat
Chemical Name: (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-carboxybutyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
CAS Number: 95153-31-4
Molecular Formula: C₁₇H₂₈N₂O₅
Molecular Weight: 340.415
Catalog: API Circulatory system medication Antihypertensive drug
Create Date: 2018-08-13 15:20:24
Modify Date: 2024-01-02 02:35:22
Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC50 value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research[1][2].

Name	(2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-carboxybutyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid
Synonyms	(2S-(1(R(R)),2a,3ab,7ab))-Octahydro-1-(2-((1-carboxybutyl)amino)-1-oxopropyl)-1H-indole-2-carboxylic Acid (2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic acid Perindoprilat (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-carboxybutyl]amino]-propanoyl]octahydro-1H-indole-2-carboxylic acid (2S,3aS,7aS)-1-[(2S)-2-{[(1S)-1-Carboxybutyl]amino}propanoyl]octahydro-1H-indole-2-carboxylic acid S-9780 Perindoprilato [Spanish] Perindoprilate [French] UNII-2UV6ZNQ92K Perindoprilatum [Latin]

Description	Perindoprilat (S 9780) is an angiotensin-converting enzyme (ACE) inhibitor with the IC50 value ranging from 1.5 to 3.2 nM. Perindoprilat can be used in hypertension research[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
In Vitro	Perindoprilat (1 μM, 10 days) treatment suppresses the angiotensin II production in HNSCC cells[3]. Cell Viability Assay[3] Cell Line: HNSCC cells Concentration: 1 μM Incubation Time: 10 days Result: Suppressed the angiotensin II production in HNSCC cells (P=0.028).
References	[1]. Perindopril. Expert Opin Pharmacother. 2006 Jan;7(1):63-71. [2]. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE. Eur J Pharmacol. 2007 Dec 22;577(1-3):1-6.

CHEMICAL NAME :: 1H-Indole-2-carboxylic acid, octahydro-1-(2-((1-carboxybutyl)amino)-1-oxopropyl)-, (2S-(1(R*(R*)),2-alpha,3a-beta,7a-beta))-

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 10,446,1992

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CDREEA Cardiovascular Drug Reviews. (Raven Press, 1185 Avenue of the Americas, New York, NY 10036) V.6- 1988- Volume(issue)/page/year: 10,446,1992

RIDADR	NONH for all modes of transport

107133-36-8

~72%

95153-31-4

Literature: Pascard; Guilhem; Vincent; Remond; Portevin; Laubie Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 663 - 669

107133-36-8

~0%

129970-98-5

95153-31-4

Literature: WO2007/58634 A1, ; Page/Page column 17-19 ;

Precursor 1
107133-36-8
DownStream 0