139026-66-7

139026-66-7 structure

Name: (Lys8-psi(CH2NH)Lys9)-Neurotensin (8-13)
Chemical Name: jmv 449
CAS Number: 139026-66-7
Molecular Formula: C₃₈H₆₆N₈O₇
Molecular Weight: 746.980
Catalog: Signaling Pathways GPCR/G Protein Neurotensin Receptor
Create Date: 2017-06-27 11:03:40
Modify Date: 2024-01-22 19:50:56
JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC50 of 0.5 nM in binding to mouse brain membranes and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse[1][2].

Name	jmv 449
Synonyms	L-Leucine, N-[(2S)-2,6-diaminohexyl]-L-lysyl-L-prolyl-L-tyrosyl-L-isoleucyl- N-[(2S)-2,6-Diaminohexyl]-L-lysyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine m.w. 746.96 c38h66n8o7

Description	JMV 449 is a potent neurotensin receptor agonist. JMV 449 shows an IC50 of 0.5 nM in binding to mouse brain membranes and an EC50 of 1.9 nM in contracting the guinea-pig ileum. JMV 449 has highly potent and long-lasting hypothermic and analgesic effects in the mouse[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurotensin Receptor Research Areas >> Neurological Disease
References	[1]. Lugrin D, et al. Reduced peptide bond pseudopeptide analogues of neurotensin: binding and biological activities, and in vitro metabolic stability. Eur J Pharmacol. 1991;205(2):191-198. [2]. Dubuc I, et al JMV 449: a pseudopeptide analogue of neurotensin-(8-13) with highly potent and long-lasting hypothermic and analgesic effects in the mouse. Eur J Pharmacol. 1992;219(2):327-329.