130495-35-1
130495-35-1 structure
- Name: SKF-96365
- Chemical Name: 1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole,hydrochloride
- CAS Number: 130495-35-1
- Molecular Formula: C22H27ClN2O3
- Molecular Weight: 402.914
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2018-12-22 12:32:26
- Modify Date: 2024-01-02 17:34:26
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SKF-96365 hydrochloride is a non-selective TRP Channel blocker.
| Name | 1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole,hydrochloride |
|---|---|
| Synonyms |
UNII:33BI32858P
1H-Imidazole, 1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]-, hydrochloride (1:1) MFCD00236407 1-{2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl}-1H-imidazole hydrochloride (1:1) SKF 96365 SKF-96365 hydrochloride SKF 96365 HCI |
| Description | SKF-96365 hydrochloride is a non-selective TRP Channel blocker. |
|---|---|
| Related Catalog | |
| Target |
TRP Channel[1] |
| In Vitro | SKF-96365 exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells. SKF-96365 inhibits hERG current in a concentration-dependent manner[1]. SKF-96365 can induces cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 treatment inhibits the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade. Overexpression of CaMKIIγ or AKT abolishes the effects of SKF-96365 on cancer cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects[2]. |
| In Vivo | SKF-96365 inhibits CRC cell growth in vivo. SKF-96365 treatment results in a decrease of p-CaMKII and p-AKT as well as an increase in LC3-II, cleaved PARP, caspase-3, and caspase-9 in mice[2]. |
| Animal Admin | Mice: Five to six-week-old female athymic BALB/c mice are inoculated into the right oxter with HCT116 cells. When the diameter of the subcutaneous tumor reaches approximately 0.5 cm, animals are randomLy assigned to the vehicle, SKF-96365 alone, HCQ alone or SKF-96365+HCQ. SKF-96365 is applied (20 mg/kg) and HCQ is applied (60 mg/kg) daily for 14 successive days by i.p. injection. Tumor sizes and volume are determined. Eight mice are included in each group. Mice are sacrificed 24 h after the last treatment. The tumors are weighed and processed for western blot analysis or paraffin embedding[2]. |
| References |
| Boiling Point | 556ºC at 760mmHg |
|---|---|
| Melting Point | 119 °C |
| Molecular Formula | C22H27ClN2O3 |
| Molecular Weight | 402.914 |
| Flash Point | 290.1ºC |
| Exact Mass | 402.171021 |
| PSA | 45.51000 |
| LogP | 5.09300 |
| Appearance | solid | white |
| Vapour Pressure | 7.86E-12mmHg at 25°C |
| Storage condition | Store at RT |
| Water Solubility | H2O: >20 mg/mL |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933290090 |
| HS Code | 2933290090 |
|---|---|
| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |