23047-25-8
23047-25-8 structure
- Name: Lofepramine
- Chemical Name: lofepramine
- CAS Number: 23047-25-8
- Molecular Formula: C26H27ClN2O
- Molecular Weight: 418.95800
- Catalog: Signaling Pathways Others Others
- Create Date: 2018-05-18 08:00:00
- Modify Date: 2024-01-02 11:37:08
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Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties[1].
| Name | lofepramine |
|---|---|
| Synonyms |
1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone
Lofepramine |
| Description | Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties[1]. |
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| Related Catalog | |
| References |
| Density | 1.173g/cm3 |
|---|---|
| Boiling Point | 575ºC at 760mmHg |
| Molecular Formula | C26H27ClN2O |
| Molecular Weight | 418.95800 |
| Flash Point | 301.6ºC |
| Exact Mass | 418.18100 |
| PSA | 23.55000 |
| LogP | 5.84650 |
| Vapour Pressure | 3.17E-13mmHg at 25°C |
| Index of Refraction | 1.607 |
| Hazard Codes | Xi |
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