23047-25-8

23047-25-8 structure

Name: Lofepramine
Chemical Name: lofepramine
CAS Number: 23047-25-8
Molecular Formula: C₂₆H₂₇ClN₂O
Molecular Weight: 418.95800
Catalog: Signaling Pathways Others Others
Create Date: 2018-05-18 08:00:00
Modify Date: 2024-01-02 11:37:08
Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties[1].

Name	lofepramine
Synonyms	1-(4-chlorophenyl)-2-[3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl-methylamino]ethanone Lofepramine

Description	Lofepramine (Lopramine) is a potent tricyclic antidepressant and is extensively metabolised to Desipramine. The antidepressant activity of Lofepramine stems from the facilitation of noradrenergic neurotransmission by uptake inhibition. Lofepramine may also potentiate serotoninergic neurotransmission by inhibition of the neuronal uptake of serotonin and the enzyme tryptophan pyrrolase. Lofepramine has significant anxiolytic efficacy in addition to its antidepressant properties[1].
Related Catalog	Signaling Pathways >> Others >> Others
References	[1]. Lancaster SG, et al. Lofepramine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness. Drugs. 1989 Feb;37(2):123-40.

Hazard Codes	Xi

Precursor 2
50-47-5 536-38-9
DownStream 0