200933-14-8

200933-14-8 structure

Name: m-3M3FBS
Chemical Name: 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide
CAS Number: 200933-14-8
Molecular Formula: C₁₆H₁₆F₃NO₂S
Molecular Weight: 343.36400
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-12-29 20:47:39
Modify Date: 2024-01-01 17:49:48
m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis[1][2][3].

Name	2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide
Synonyms	Tocris-1941 Phospholipase C Activator,m-3M3FBS N-(3-Trifluoromethylphenyl)-2,4,6-trimethylbenzenesulfonamide m-3M3FBS

Description	m-3M3FBS is a potent phospholipase C (PLC) activator. m-3M3FBS stimulates superoxide generation in human neutrophils, upregulates intracellular calcium concentration, and stimulates inositol phosphate generation in various cell lines. m-3M3FBS induces monocytic leukemia cell apoptosis[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase
In Vitro	m-3M3FBS (5-50 μM) stimulates the formation of inositol phosphates in U937 cells[1]. m-3M3FBS (50 μM; 24 hours) inhibits the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes[3]. m-3M3FBS (50 μM; 24 hours) induces U937 cell apoptosis[3]. Cell Viability Assay[3] Cell Line: U937 and THP-1 cells Concentration: 50 μM Incubation Time: 24 hours Result: Inhibited the growth of the leukemic cell lines U937 and THP-1, but not primary monocytes. Cell Viability Assay[3] Cell Line: U937 cells Concentration: 50 μM Incubation Time: 24 hours Result: The apoptotic rate of m-3M3FBS-treated cells was 53.9%.
References	[1]. Bae YS, et al. Identification of a compound that directly stimulates phospholipase C activity. Mol Pharmacol. 2003;63(5):1043-1050. [2]. Krjukova J, et al. Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation. Br J Pharmacol. 2004;143(1):3-7. [3]. Lee YN, et al. The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis. Cancer Lett. 2005;222(2):227-235.

Density	1.316g/cm3
Boiling Point	420ºC at 760mmHg
Melting Point	114-114.8ºC(lit.)
Molecular Formula	C₁₆H₁₆F₃NO₂S
Molecular Weight	343.36400
Flash Point	207.8ºC
Exact Mass	343.08500
PSA	54.55000
LogP	5.58520
Vapour Pressure	2.92E-07mmHg at 25°C
Index of Refraction	1.547

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2935009090

HS Code	2935009090
Summary	2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

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