Shanghai Nianxing Industrial Co., Ltd
China
Product Name: MK886
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: MK-886
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: MK 886
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

118414-82-7

118414-82-7 structure

118414-82-7 structure

Name: MK886
Chemical Name: 3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoic acid
CAS Number: 118414-82-7
Molecular Formula: C₂₇H₃₄ClNO₂S
Molecular Weight: 472.08
Catalog: Signaling Pathways Immunology/Inflammation FLAP
Create Date: 2018-12-21 01:18:00
Modify Date: 2024-01-08 11:59:15
MK886 is a 5-lipoxygenase-activating protein inhibitor and a leukotriene biosynthesis inhibitor (IC50=2.5 nM).

Name	3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoic acid
Synonyms	Sodium 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropanoate 1H-Indole-2-propanoic acid, 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-, sodium salt (1:1) Pizotifenum Pizotifene SIN-1 chloride PIZOTYLINE Sandomygran BC-105 Pizotifeno Litec Pizotifen Sandomigran Polomigran Sodium 3-{1-(4-chlorobenzyl)-5-isopropyl-3-[(2-methyl-2-propanyl)sulfanyl]-1H-indol-2-yl}-2,2-dimethylpropanoate MK-886

Description	MK886 is a 5-lipoxygenase-activating protein inhibitor and a leukotriene biosynthesis inhibitor (IC50=2.5 nM).
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> FLAP Research Areas >> Cancer
References	[1]. [1] Kehrer JP et al. Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886. Biochem J. 2001 Jun 15. [2]. [2] Gillard J et al. L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol. 1989 May;67(5):456-64. [3]. [3] Dixon RA et al. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature, 1990 Jan 18, 343(6255):282-4.http://www.ncbi.nlm.nih.gov/pubmed/2300173

Density	1.14g/cm3
Boiling Point	623.4ºC at 760mmHg
Melting Point	295-297ºC
Molecular Formula	C₂₇H₃₄ClNO₂S
Molecular Weight	472.08
Flash Point	330.8ºC
PSA	70.36000
LogP	6.67560
Vapour Pressure	2.11E-16mmHg at 25°C
Index of Refraction	1.58
Storage condition	-20℃

WGK Germany	3