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  • DC Chemicals Limited
  • China
  • Product Name: SIS3
  • Price: $600.0/100mg $1200.0/250mg $2400.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

521984-48-5

521984-48-5 structure
521984-48-5 structure
  • Name: SIS3
  • Chemical Name: sis3
  • CAS Number: 521984-48-5
  • Molecular Formula: C28H28ClN3O3
  • Molecular Weight: 489.993
  • Catalog: Signaling Pathways Stem Cell/Wnt TGF-beta/Smad
  • Create Date: 2016-06-26 20:55:15
  • Modify Date: 2024-01-02 09:33:22
  • SIS3 is a cell-permeable and selective inhibitor of Smad3. It inhibits Smad3 phosphorylation with an IC50 of 3 µM.

Name sis3
Synonyms (2E)-1-(6,7-Dimethoxy-3,4-dihydro-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-2-propen-1-one hydrochloride (1:1)
2-Propen-1-one, 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-, (2E)-, hydrochloride (1:1)
Boiling Point 737.2ºC at 760 mmHg
Molecular Formula C28H28ClN3O3
Molecular Weight 489.993
Flash Point 399.7ºC
Exact Mass 489.181915
PSA 56.59000
LogP 5.59550
Storage condition -20℃
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport