Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CP-101,606
Price:
Purity: 99.0%
Stocking Period: 10 Day
Contact: Yang

DC Chemicals Limited
China
Product Name: Traxoprodil
Price: $450.0/100mg $850.0/250mg $1800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
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ShangHai DC Chemicals Co.,Ltd
China
Product Name: Traxoprodil
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-((1S,2S)-1-HYDROXY-1-(4-HYDROXYPHENYL)PROPAN-2-YL)-4-PHENYLPIPERIDIN-4-OL
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

134234-12-1

134234-12-1 structure

134234-12-1 structure

Name: CP-101,606
Chemical Name: 1-((1S,2S)-1-Hydroxy-1-(4-hydroxyphenyl)propan-2-yl)-4-phenylpiperidin-4-ol
CAS Number: 134234-12-1
Molecular Formula: C₂₀H₂₅NO₃
Molecular Weight: 327.417
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2018-04-27 08:00:00
Modify Date: 2024-01-06 12:11:21
Traxoprodil (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM.

Name	1-((1S,2S)-1-Hydroxy-1-(4-hydroxyphenyl)propan-2-yl)-4-phenylpiperidin-4-ol
Synonyms	1-[(1S,2S)-1-Hydroxy-1-(4-hydroxyphenyl)-2-propanyl]-4-phenyl-4-piperidinol 1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl)-4-phenylpiperidin-4-ol 1-[(1S,2S)-2-Hydroxy-2-(4-hydroxy-phenyl)-1-methyl-ethyl]-4-phenyl-piperidin-4-ol traxoprodil CP 101606 1-Piperidineethanol, 4-hydroxy-α-(4-hydroxyphenyl)-β-methyl-4-phenyl-, (αS,βS)- (1S,2S)-1-(4-hydroxy-phenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol

Description	Traxoprodil (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease
Target	IC50: 10 nM (Neuroprotection)[1]
In Vivo	Traxoprodil is potent at blocking haloperidol-induced catalepsy and with an ED50 less than 1 mg/kg. Traxoprodil is effective at 1 mg/kg to block NMDA (ip) stimulated cfos induction in mice[1]. Traxoprodil at a dose of 20 and 40 mg/kg exhibits antidepressant activity in the Forced swim test and it is not related to changes in animals’ locomotor activity[2]. Traxoprodil (20 nM i.c.v.) increases the latency to generalized tonic-clonic seizures induced by PTZ (70 mg/kg; i.p.). Traxoprodil (60 mg/kg, p.o.) increases the latency to clonic and generalized seizures, and decreases the total time spent in seizures[3].
Animal Admin	Rats[3] The effect of traxoprodil and SPD on PTZ-induced seizures is investigated by injecting the Adult (90-100 days-old) male Wistar rats (250-300 g) with traxoprodil (0.2, 2 or 20 nM/site), SPD (0.02, 0.2 or 2 nM/site), or with vehicle (0.9% NaCl, 1 μL) 15 min before the administration of PTZ (35 or 70 mg/kg, i.p.)[3]. Mice[2] The Forced swim test is done on male Albino Swiss mice (25-30 g). Traxoprodil (5, 10, 20, 40 mg/kg), imipramine and saline are administered i.p. 60 min before the test. The antidepressant activity is measured[2].
References	[1]. Chenard BL, et al. (1S,2S)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4-phenylpiperidino)-1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. J Med Chem. 1995 Aug 4;38(16):3138-45. [2]. Poleszak E, et al. Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice. Metab Brain Dis. 2016 Aug;31(4):803-14. [3]. Naspolini AP, et al. Traxoprodil decreases pentylenetetrazol-induced seizures. Epilepsy Res. 2012 Jun;100(1-2):12-9.

Density	1.2±0.1 g/cm3
Boiling Point	534.4±50.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₅NO₃
Molecular Weight	327.417
Flash Point	290.3±28.8 °C
Exact Mass	327.183441
PSA	63.93000
LogP	1.75
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.626
Storage condition	2-8℃

Symbol	GHS06, GHS09
Signal Word	Danger
Hazard Statements	H301-H319-H400
Precautionary Statements	P273-P301 + P310-P305 + P351 + P338
RIDADR	UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all