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23815-87-4

23815-87-4 structure
23815-87-4 structure
  • Name: Bradykinin Fragment 1-7
  • Chemical Name: h-arg-pro-pro-gly-phe-ser-pro-oh acetate salt
  • CAS Number: 23815-87-4
  • Molecular Formula: C35H52N10O9
  • Molecular Weight: 756.84900
  • Catalog: Biochemical Peptide
  • Create Date: 2018-06-08 09:21:50
  • Modify Date: 2024-01-04 17:14:31
  • Bradykinin (1-7) is an amino-truncated Bradykinin peptide. Bradykinin (1-7) is a metabolite of Bradykinin, cleaved by endopeptidase.

Name h-arg-pro-pro-gly-phe-ser-pro-oh acetate salt
Synonyms des-phe(8)-des-arg(9)-bradykini
H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-OH
MFCD00076262
BRADYKININ FRAGMENT 1-7
BRADYKININ (1-7)
RPPGFSP
Arg-Pro-Pro-Gly-Phe-Ser-Pro-OH
bradykinin,des-Phe(8)-des-Arg(9)
ARG-PRO-PRO-GLY-PHE-SER-PRO ACETATE
BRADYKININ 1-7 ACETATE
ARG-PRO-PRO-GLY-PHE-SER-PRO
Bradykinin: 1-7
Description Bradykinin (1-7) is an amino-truncated Bradykinin peptide. Bradykinin (1-7) is a metabolite of Bradykinin, cleaved by endopeptidase.
Related Catalog
In Vitro The Bradykinin peptide system is a tissue-based system with potent cardiovascular and renal effects. To investigate the regulation of this system, a highly sensitive amino terminal-directed radioimmunoassay that, with high performance liquid chromatography, enables the measurement of Bradykinin-(1-7), Bradykinin-(1-8), and Bradykinin-(1-9), is developed. Together with a carboxy terminal-directed radioimmunoassay, Bradykinin peptides in rat kidney and blood are characterized. The predominant Bradykinin peptides in kidney are Bradykinin-(1-9) (~100 fmol/g wet weight of tissue) and Bradykinin-(1-7) (~70 fmol/g), with low levels of Bradykinin-(1-8) (~8 fmol/g) and Bradykinin-(4-9) (~12 fmol/g) detectable; Bradykinin-(2-9) and Bradykinin-(3-9) are below the limits of detection. In blood, the levels of Bradykinin-(1-9) are very low (~2 fmol/ml), and other Bradykinin peptides are below the limits ofdetection. Administration of the angiotensin converting enzyme (ACE) inhibitor Perindopril is associated with an approximate twofold increase in renal levels of Bradykinin-(1-8) and Bradykinin-(1-9) and a decrease in the Bradykinin-(1-7)/Bradykinin-(1-9) ratio. The amino terminal-directed radioimmunoassay is also applied to heart, aorta, brown adipose tissue, adrenal, lung, and brain. For these tissues, Bradykinin-(1-7) and Bradykinin-(1-9) are of similar abundance (16-340 fmol/g), with lower levels of Bradykinin-(1-8)[1].
References

[1]. Campbell DJ, et al. Bradykinin peptides in kidney, blood, and other tissues of the rat. Hypertension. 1993 Feb;21(2):155-65.

Density 1.52 g/cm3
Molecular Formula C35H52N10O9
Molecular Weight 756.84900
Exact Mass 756.39200
PSA 293.68000
Index of Refraction 1.695
Storage condition −20°C
Water Solubility Soluble in water (1 mg/ml).
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes F+
RIDADR NONH for all modes of transport
WGK Germany 3