Name | h-arg-pro-pro-gly-phe-ser-pro-oh acetate salt |
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Synonyms |
des-phe(8)-des-arg(9)-bradykini
H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-OH MFCD00076262 BRADYKININ FRAGMENT 1-7 BRADYKININ (1-7) RPPGFSP Arg-Pro-Pro-Gly-Phe-Ser-Pro-OH bradykinin,des-Phe(8)-des-Arg(9) ARG-PRO-PRO-GLY-PHE-SER-PRO ACETATE BRADYKININ 1-7 ACETATE ARG-PRO-PRO-GLY-PHE-SER-PRO Bradykinin: 1-7 |
Description | Bradykinin (1-7) is an amino-truncated Bradykinin peptide. Bradykinin (1-7) is a metabolite of Bradykinin, cleaved by endopeptidase. |
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Related Catalog | |
In Vitro | The Bradykinin peptide system is a tissue-based system with potent cardiovascular and renal effects. To investigate the regulation of this system, a highly sensitive amino terminal-directed radioimmunoassay that, with high performance liquid chromatography, enables the measurement of Bradykinin-(1-7), Bradykinin-(1-8), and Bradykinin-(1-9), is developed. Together with a carboxy terminal-directed radioimmunoassay, Bradykinin peptides in rat kidney and blood are characterized. The predominant Bradykinin peptides in kidney are Bradykinin-(1-9) (~100 fmol/g wet weight of tissue) and Bradykinin-(1-7) (~70 fmol/g), with low levels of Bradykinin-(1-8) (~8 fmol/g) and Bradykinin-(4-9) (~12 fmol/g) detectable; Bradykinin-(2-9) and Bradykinin-(3-9) are below the limits of detection. In blood, the levels of Bradykinin-(1-9) are very low (~2 fmol/ml), and other Bradykinin peptides are below the limits ofdetection. Administration of the angiotensin converting enzyme (ACE) inhibitor Perindopril is associated with an approximate twofold increase in renal levels of Bradykinin-(1-8) and Bradykinin-(1-9) and a decrease in the Bradykinin-(1-7)/Bradykinin-(1-9) ratio. The amino terminal-directed radioimmunoassay is also applied to heart, aorta, brown adipose tissue, adrenal, lung, and brain. For these tissues, Bradykinin-(1-7) and Bradykinin-(1-9) are of similar abundance (16-340 fmol/g), with lower levels of Bradykinin-(1-8)[1]. |
References |
Density | 1.52 g/cm3 |
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Molecular Formula | C35H52N10O9 |
Molecular Weight | 756.84900 |
Exact Mass | 756.39200 |
PSA | 293.68000 |
Index of Refraction | 1.695 |
Storage condition | −20°C |
Water Solubility | Soluble in water (1 mg/ml). |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Hazard Codes | F+ |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |