5961-83-1

5961-83-1 structure

Name: Bis-PEG1-acid
Chemical Name: 3-(2-carboxyethoxy)propanoic acid
CAS Number: 5961-83-1
Molecular Formula: C₆H₁₀O₅
Molecular Weight: 162.14100
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-03-17 06:44:32
Modify Date: 2024-01-02 17:32:32
Bis-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

Name	3-(2-carboxyethoxy)propanoic acid
Synonyms	3,3'-oxydipropanoic acid 3-(2-carboxyethyloxy)propanoic acid 3-(2-carboxyethoxy)propionic acid 4-oxa-heptanedioic acid 3,3'-oxydipropionic acid 4-oxa-1,7-heptanedioic acid 4-Oxaheptandisaure

Description	Bis-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Hazard Codes	C

79-10-7

~4%

5961-83-1

503-66-2

Literature: CARGILL INCORPORATED Patent: WO2004/76398 A1, 2004 ; Location in patent: Page 8 ;

1427320-41-9

~90%

5961-83-1

Literature: Landeros, Jose M.; Silvestre, Hugo A.; Guadarrama, Patricia Journal of Molecular Structure, 2013 , vol. 1037, p. 412 - 419

1656-48-0

~92%

5961-83-1

Literature: Buchanan; Driega; Yap Canadian Journal of Chemistry, 2000 , vol. 78, # 3 p. 316 - 321

57-57-8

5961-83-1

Literature: Eastman Kodak Co. Patent: US2466419 , 1948 ;

57-57-8

7732-18-5

5961-83-1

Literature: Eastman Kodak Co. Patent: US2466419 , 1949 ;