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30918-54-8

30918-54-8 structure
30918-54-8 structure
  • Name: Polyinosinic acid
  • Chemical Name: 5'-Inosinic acid polymers
  • CAS Number: 30918-54-8
  • Molecular Formula: C10H13N4O8P
  • Molecular Weight: 348.206
  • Catalog: Biochemical Biological response modifier
  • Create Date: 2018-05-13 08:00:00
  • Modify Date: 2024-01-03 12:57:00
  • Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) agonist. Polyinosinic acid enhances cellular immune response through TLR3 and TRIF. Polyinosinic acid has potential applications in immune regulation[1].

Name 5'-Inosinic acid polymers
Synonyms (1S)-1,4-Anhydro-1-(6-oxo-6,7-dihydro-1H-purin-8-yl)-5-O-phosphono-D-ribitol
Polyinosinic acid (Poly I)
(1S)-1,4-Anhydro-1-(6-oxo-6,9-dihydro-3H-purin-8-yl)-5-O-phosphono-D-ribitol
Polyinosinicacid
POLY[I] POTASSIUM SALT
POLY RL POTASSIUM SALT
D-Ribitol, 1,4-anhydro-1-C-(6,9-dihydro-6-oxo-3H-purin-8-yl)-, 5-(dihydrogen phosphate), (1S)-
Polyinosinic acid
Poly(rI)
Poly(IMP)
polyinosinicacidpot.salt
Description Polyinosinic acid is a single stranded homonucleic acid, which is a Toll-like Receptor 3 (TLR3) agonist. Polyinosinic acid enhances cellular immune response through TLR3 and TRIF. Polyinosinic acid has potential applications in immune regulation[1].
Related Catalog
In Vitro Polyinosinic acid (50 µg/mL;24 h) 诱导 BALB/c B 细胞中 CD86、CD40 和 MHC II 的表达,BALB/c BMDC 细胞中 CD86 和 CD40 的表达[1]。 Polyinosinic acid (1、5 和 25 µg/mL;48 h) 以剂量依赖性方式加强了 BALB/c B 细胞对 [3H] 胸苷的摄取[1]。 Polyinosinic acid (50 µg/mL;20 h) 诱导 BALB/c BMDC 细胞和巨噬细胞分泌 TNFα 和 IL-12,BALB/c B 细胞、BMDC 细胞分泌 IFN。Polyinosinic acid 增加了 C57Bl/6、MyD88 敲除和 TLR4 敲除小鼠 B 细胞中 MHC II、CD86 的表达[1]。 Polyinosinic acid (50 µg/mL;48 h) 加强了 C57Bl/6、MyD88 敲除和 TLR4 敲除小鼠 B 细胞对胸苷的摄取[1]。 Polyinosinic acid (25 µg/mL 和 50 µg/mL;24 h) 以剂量依赖性方式诱导 BEAS-2B 细胞分泌 IP-10[1]。 Polyinosinic acid (50 µg/mL;24 h 或 48 h) 通过 TRIF 调节 TRIF+/+ 和 TRIF-/- 小鼠 B 细胞中 CD86 的表达及胸苷的摄取[1]。 Polyinosinic acid (10、20 或 50 µg/mL;20 h) 增加了 TLR3+/+ 来源的 BMDC 细胞分泌 IFN 和 IFNα,但不影响 TLR3-/- 来源的 BMDC 细胞[1]。
References

[1]. Marshall-Clarke S, et al. Polyinosinic acid is a ligand for toll-like receptor 3. J Biol Chem. 2007 Aug 24;282(34):24759-66.  

Density 2.4±0.1 g/cm3
Boiling Point 905.4±75.0 °C at 760 mmHg
Molecular Formula C10H13N4O8P
Molecular Weight 348.206
Flash Point 501.4±37.1 °C
Exact Mass 348.047089
PSA 189.83000
LogP -2.65
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.918
Storage condition −20°C
WGK Germany 3