317326-90-2

317326-90-2 structure

Name: HLI-98C
Chemical Name: 10-(3-chlorophenyl)-7-nitropyrimido[4,5-b]quinoline-2,4-dione
CAS Number: 317326-90-2
Molecular Formula: C₁₇H₉ClN₄O₄
Molecular Weight: 368.73100
Catalog: Signaling Pathways Apoptosis MDM-2/p53
Create Date: 2016-06-17 10:00:28
Modify Date: 2024-02-08 17:55:12
HLI98C is a ubiquitin ligase inhibitor. HLI98C inhibits p53 ubiquitylation. HLI98C inhibits HDM2 auto-ubiquitylation[1].

Name	10-(3-chlorophenyl)-7-nitropyrimido[4,5-b]quinoline-2,4-dione
Synonyms	HLI-98C

Description	HLI98C is a ubiquitin ligase inhibitor. HLI98C inhibits p53 ubiquitylation. HLI98C inhibits HDM2 auto-ubiquitylation[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> MDM-2/p53 Signaling Pathways >> Metabolic Enzyme/Protease >> E1/E2/E3 Enzyme
Target	ubiquitin ligase[1]
References	[1]. Yang Y, et al. Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell. 2005 Jun;7(6):547-59.