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  • DC Chemicals Limited
  • China
  • Product Name: NSC2805
  • Price: ¥650.0/100mg ¥1100.0/250mg ¥4300.0/1g
  • Purity: 98.0%
  • Stocking Period: 1 Day
  • Contact: Tony Cao


4371-34-0

4371-34-0 structure
4371-34-0 structure
  • Name: 4,4-dimethyl[1,1-biphenyl]-2,2,5,5-tetrol
  • Chemical Name: 2-(2,5-dihydroxy-4-methylphenyl)-5-methylbenzene-1,4-diol
  • CAS Number: 4371-34-0
  • Molecular Formula: C14H14O4
  • Molecular Weight: 246.25900
  • Catalog: Research Areas Cancer
  • Create Date: 2016-10-08 10:58:06
  • Modify Date: 2024-01-14 12:42:33
  • NSC2805 is a WWP2 ubiquitin ligase inhibitor that can significant inhibit WWP2 activity with an IC50 of 0.38 μM. NSC2805 can be used for the research of cancer[1].

Name 2-(2,5-dihydroxy-4-methylphenyl)-5-methylbenzene-1,4-diol
Synonyms 4.4'-Dimethyl-biphenyltetrol-(2.5.2'.5')
2.5.2'.5'-Tetraoxy-4.4'-dimethyl-diphenyl
2.5.2'.5'-Tetrahydroxy-4.4'-dimethyl-biphenyl
2.5.2'.5'-Tetraoxy-ditolyl-(4.4')
4,4'-dimethyl[1,1'-biphenyl]-2,2',5,5'-tetrol
4,4'-Dimethyl-biphenyl-2,5,2',5'-tetraol
Description NSC2805 is a WWP2 ubiquitin ligase inhibitor that can significant inhibit WWP2 activity with an IC50 of 0.38 μM. NSC2805 can be used for the research of cancer[1].
Related Catalog
In Vitro NSC2805 has WWP2 inhibitory activity with an IC50 of 0.38 μM[1]. NSC2805 shows a significant reduction in activity for all three proteins (WWP2, WWP1 and Nedd4)[1]. NSC2805 can robustly inhibit WWP2-dependent PTEN ubiquitination[1].
References

[1]. Jessica E Watt, et al. Discovery of Small Molecule WWP2 Ubiquitin Ligase Inhibitors. Chemistry. 2018 Dec 3;24(67):17677-17680.

Density 1.36g/cm3
Boiling Point 501.6ºC at 760 mmHg
Molecular Formula C14H14O4
Molecular Weight 246.25900
Flash Point 248.2ºC
Exact Mass 246.08900
PSA 80.92000
LogP 2.79280
Index of Refraction 1.675
HS Code 2906299090
HS Code 2906299090
Summary 2906299090 other aromatic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%