255906-59-3

255906-59-3 structure

Name: VK3-OCH3
Chemical Name: 2-[(2-Methoxy)ethylthio]-3-methyl-1,4-naphthoquinone
CAS Number: 255906-59-3
Molecular Formula: C₁₄H₁₄O₃S
Molecular Weight: 262.32400
Catalog: Research Areas Cancer
Create Date: 2018-06-26 20:24:51
Modify Date: 2024-01-04 10:58:29
VK3-OCH3 is a potent antitumor agent. VK3-OCH3 shows cytotoxicity for neuroblastoma cell lines and low cytotoxicity for normal cell lines. VK3-OCH3 induces apoptosis and cell cycle arrest at G2/M phase in IMR-32 cells. VK3-OCH3 shows antitumor activity[1].

Name	2-[(2-Methoxy)ethylthio]-3-methyl-1,4-naphthoquinone
Synonyms	2-[(2-Methoxyethyl)thio]-3-methyl-1,4-napthalenedione 2-(2-methoxyethylsulfanyl)-3-methylnaphthalene-1,4-dione

Description	VK3-OCH3 is a potent antitumor agent. VK3-OCH3 shows cytotoxicity for neuroblastoma cell lines and low cytotoxicity for normal cell lines. VK3-OCH3 induces apoptosis and cell cycle arrest at G2/M phase in IMR-32 cells. VK3-OCH3 shows antitumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	VK3-OCH3 (compound 5) shows cytotoxicity with IC50s of 2.43, 1.55, 10.69, 3.45, 26.24, 87.11 µM for IMR-32, LA-N-1, NB-39, SK-N-SH, HUVEC, HDF cells, respectively[1]. VK3-OCH3 (1, 3, 10 µM) induces apoptosis and cell cycle arrest at G2/M phase in IMR-32 cells[1]. VK3-OCH3 (0-48 h) increases the expression of HO-1 in 8~24 h, and Caveolin-1 in 48 h in IMR-32 and LA-N-1 cells[1]. VK3-OCH3 (0-48 h) increases the expression of phospho-p38-MAPK and decreases the expression of p21 and clusterin[1].
References	[1]. Kitano T, et al. Vitamin K3 analogs induce selective tumor cytotoxicity in neuroblastoma. Biol Pharm Bull. 2012;35(4):617-23.

HS Code	2930909090
Summary	2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%